![]() Similarly, the reported changes in wakefulness or non-rapid eye movement sleep (slow-wave sleep SWS) with manipulation of the MCH system using conditional genetic methods are inconsistent. While almost all studies using “gain-of-function” approaches show an increase in rapid eye movement sleep (or paradoxical sleep PS), loss-of-function approaches have not shown reductions in PS. We review recent data on this aspect, which are mostly inconsistent, and propose a novel role for MCH neurons in sleep regulation. However, the precise role of MCH neurons in sleep-wake regulation has remained unclear, despite several years of research employing a wide range of techniques. Melanin-concentrating hormone (MCH)–expressing neurons located in the lateral hypothalamus are considered as an integral component of sleep-wake circuitry.
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